Action of Mepacrine on Diamine Oxidase

Diamine oxidase and cadaverine metabolism.

We have recently presented evidence that diamine oxidase is rcsponsiblc for a portion of the metabolism of histamine in several species (1, 2). This evidence is largely based on the alteration of histamine metabolism produced by compounds which are known to inhibit diamine oxidase in vitro. The inhibitors used were isonicotinylhydrazine (3) and aminoguanidine. The latter is reported to be the m...

The Inhibition of Human Placental Diamine Oxidase

1. The oxidation of p-dimethylaminomethylbenzylamine by purified placental diamine oxidase was followed by measuring the change in E250 caused by the production of p-dimethylaminomethylbenzaldehyde. 2. The inhibition of this reaction by substrate analogues such as isothiouronium, guanidinium, dimethylsulphonium and trimethylammonium compounds was extensively studied. 3. The type and degree of i...

Diamine oxidase activity levels in anorexia nervosa.

OBJECTIVE Anorexia nervosa (AN) patients often experience gastrointestinal complications caused by their malnutrition. We hypothesized that intestinal integrity is disturbed in AN. Therefore, the objective of the present study was to investigate serum diamine oxidase (DAO) activity, which is considered to be a clinical indicator of the integrity of the intestinal mucosa, in AN patients. METHO...

Mepacrine Psychosis

Mepacrine Psychosis

Sib,?It does not seem that a full case has been made against mepacrine by Drs. M. S. H. Mody and Nandi writing about mepacrine psychosis in your issue of May 1947, pages 273-274. It is not said whether their cases were clinical or proven by an examination of the blood-films. It would also be necessary to exclude meningitis by making a lumbar puncture before they can dub mepacrine as the causati...